ROS-Sensitive Polymeric Nanocarriers with Red Light-Activated
Size Shrinkage for Remotely Controlled Drug Release
Ziyang Cao
Yinchu Ma
Chunyang Sun
Zidong Lu
Zeyu Yao
Junxia Wang
Dongdong Li
Youyong Yuan
Xianzhu Yang
10.1021/acs.chemmater.7b04751.s001
https://acs.figshare.com/articles/journal_contribution/ROS-Sensitive_Polymeric_Nanocarriers_with_Red_Light-Activated_Size_Shrinkage_for_Remotely_Controlled_Drug_Release/5768130
Drug
delivery systems with remotely controlled drug release capability
are rather attractive options for cancer therapy. Herein, a reactive
oxygen species (ROS)-sensitive polymeric nanocarrier TK-PPE@NP<sub>Ce6/DOX</sub> was explored to realize remotely controlled drug release
by light-activated size shrinkage. The TK-PPE@NP<sub>Ce6/DOX</sub> encapsulating chlorin e6 (Ce6) and doxorubicin (DOX) was self-assembled
from an innovative ROS-sensitive polymer TK-PPE with the assistance
of an amphiphilic copolymer poly(ethylene glycol)-<i>b</i>-poly(ε-caprolactone) (PEG-<i>b</i>-PCL). Under the
660 nm red light irradiation, ROS generated by the encapsulated Ce6
were capable of cleaving the TK linker <i>in situ</i>, which
resulted in the rapid degradation of the TK-PPE@NP<sub>Ce6/DOX</sub> core. Consequently, the size of TK-PPE@NP<sub>Ce6/DOX</sub> shrank
from 154 ± 4 nm to 72 ± 3 nm, and such size shrinkage affected
further triggered rapid DOX release. As evidenced by both <i>in vitro</i> and <i>in vivo</i> experiments, such
ROS-sensitive polymeric nanocarriers with light-induced size shrinkage
capability offer remarkable therapeutic effects in cancer treatment.
This concept provides new avenues for the development of light-activated
drug delivery systems for remotely controlled drug release <i>in vivo</i>.
2017-12-22 00:00:00
drug release capability
drug release
light-induced size shrinkage capability offer
ROS-sensitive polymer TK-PPE
size shrinkage
PCL
encapsulated Ce 6
reactive oxygen species
DOX
Red Light-Activated Size Shrinkage
PEG
ROS-Sensitive Polymeric Nanocarriers
nm
drug delivery systems
Remotely Controlled Drug Release Drug delivery systems