Peng, Xinyi Wang, Rui Wang, Tingjian Yang, Wanning Wang, Hao Gu, Wei Ye, Ling Carbon Dots/Prussian Blue Satellite/Core Nanocomposites for Optical Imaging and Photothermal Therapy Integration of optical imaging modality with photothermal therapy (PTT) for simultaneously providing oncotherapy and bioimaging enables an optimized therapeutic efficacy and higher treatment accuracy and therefore has emerged as a prospective cancer treatment. However, it remains challenging to develop biocompatible PTT nanoagents capable of imaging, monitoring, and diagnosis. Carbon dots (CDs) possess unique photoluminescent (PL) properties and intrinsic biocompatibility; while Prussian blue nanoparticles (PBNPs) are nontoxic with efficient photothermal conversion capacity for PTT. Herein, a simple, cost-effective, and environmentally benign method was developed to strategically fabricate CD-decorated PBNP (CDs/PBNP) nanocomposites with satellite/core structure. The CDs/PBNPs possess distinct green PL emission and near-infrared photoabsorption with high efficiency and photothermal stability. In vitro and in vivo toxicity tests prove the biocompatibility of the CDs/PBNPs. Moreover, the applicability of CDs/PBNPs as nanotheranostic agents was tested, which suggests that CDs/PBNPs possess promising imaging and effective tumor ablation properties. vivo toxicity tests;treatment accuracy;Photothermal Therapy Integration;near-infrared photoabsorption;carbon dots;biocompatible PTT nanoagents;CD-decorated PBNP;cancer treatment;photothermal therapy;imaging modality;PL emission;tumor ablation properties;photothermal stability;photothermal conversion capacity;nanotheranostic agents;Optical Imaging 2017-12-18
    https://acs.figshare.com/articles/journal_contribution/Carbon_Dots_Prussian_Blue_Satellite_Core_Nanocomposites_for_Optical_Imaging_and_Photothermal_Therapy/5734965
10.1021/acsami.7b14972.s001