10.1021/acsami.7b14972.s001
Xinyi Peng
Xinyi
Peng
Rui Wang
Rui
Wang
Tingjian Wang
Tingjian
Wang
Wanning Yang
Wanning
Yang
Hao Wang
Hao
Wang
Wei Gu
Wei
Gu
Ling Ye
Ling
Ye
Carbon
Dots/Prussian Blue Satellite/Core Nanocomposites for Optical Imaging
and Photothermal Therapy
American Chemical Society
2017
vivo toxicity tests
treatment accuracy
Photothermal Therapy Integration
near-infrared photoabsorption
carbon dots
biocompatible PTT nanoagents
CD-decorated PBNP
cancer treatment
photothermal therapy
imaging modality
PL emission
tumor ablation properties
photothermal stability
photothermal conversion capacity
nanotheranostic agents
Optical Imaging
2017-12-18 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Carbon_Dots_Prussian_Blue_Satellite_Core_Nanocomposites_for_Optical_Imaging_and_Photothermal_Therapy/5734965
Integration
of optical imaging modality with photothermal therapy (PTT) for simultaneously
providing oncotherapy and bioimaging enables an optimized therapeutic
efficacy and higher treatment accuracy and therefore has emerged as
a prospective cancer treatment. However, it remains challenging to
develop biocompatible PTT nanoagents capable of imaging, monitoring,
and diagnosis. Carbon dots (CDs) possess unique photoluminescent (PL)
properties and intrinsic biocompatibility; while Prussian blue nanoparticles
(PBNPs) are nontoxic with efficient photothermal conversion capacity
for PTT. Herein, a simple, cost-effective, and environmentally benign
method was developed to strategically fabricate CD-decorated PBNP
(CDs/PBNP) nanocomposites with satellite/core structure. The CDs/PBNPs
possess distinct green PL emission and near-infrared photoabsorption
with high efficiency and photothermal stability. In vitro and in vivo
toxicity tests prove the biocompatibility of the CDs/PBNPs. Moreover,
the applicability of CDs/PBNPs as nanotheranostic agents was tested,
which suggests that CDs/PBNPs possess promising imaging and effective
tumor ablation properties.