10.1021/acsami.7b14972.s001 Xinyi Peng Xinyi Peng Rui Wang Rui Wang Tingjian Wang Tingjian Wang Wanning Yang Wanning Yang Hao Wang Hao Wang Wei Gu Wei Gu Ling Ye Ling Ye Carbon Dots/Prussian Blue Satellite/Core Nanocomposites for Optical Imaging and Photothermal Therapy American Chemical Society 2017 vivo toxicity tests treatment accuracy Photothermal Therapy Integration near-infrared photoabsorption carbon dots biocompatible PTT nanoagents CD-decorated PBNP cancer treatment photothermal therapy imaging modality PL emission tumor ablation properties photothermal stability photothermal conversion capacity nanotheranostic agents Optical Imaging 2017-12-18 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Carbon_Dots_Prussian_Blue_Satellite_Core_Nanocomposites_for_Optical_Imaging_and_Photothermal_Therapy/5734965 Integration of optical imaging modality with photothermal therapy (PTT) for simultaneously providing oncotherapy and bioimaging enables an optimized therapeutic efficacy and higher treatment accuracy and therefore has emerged as a prospective cancer treatment. However, it remains challenging to develop biocompatible PTT nanoagents capable of imaging, monitoring, and diagnosis. Carbon dots (CDs) possess unique photoluminescent (PL) properties and intrinsic biocompatibility; while Prussian blue nanoparticles (PBNPs) are nontoxic with efficient photothermal conversion capacity for PTT. Herein, a simple, cost-effective, and environmentally benign method was developed to strategically fabricate CD-decorated PBNP (CDs/PBNP) nanocomposites with satellite/core structure. The CDs/PBNPs possess distinct green PL emission and near-infrared photoabsorption with high efficiency and photothermal stability. In vitro and in vivo toxicity tests prove the biocompatibility of the CDs/PBNPs. Moreover, the applicability of CDs/PBNPs as nanotheranostic agents was tested, which suggests that CDs/PBNPs possess promising imaging and effective tumor ablation properties.