%0 Journal Article %A Zhang, Song-Lin %A Wan, Hai-Xing %A Bie, Wen-Feng %D 2017 %T syn-Fluoro- and -Oxy-trifluoromethylation of Arylacetylenes %U https://acs.figshare.com/articles/journal_contribution/_i_syn_i_-Fluoro-_and_-Oxy-trifluoromethylation_of_Arylacetylenes/5615443 %R 10.1021/acs.orglett.7b03229.s001 %2 https://acs.figshare.com/ndownloader/files/9775930 %K CsF %K III %K Arylacetylenes One-step %K syn mode %K phenylboronic acid %K functionalized trifluoromethylated Z %K CF 3 %X One-step concurrent fluoro-trifluoromethylation across the triple bond of arylacetylenes in a syn mode is enabled by the collaboration of (phen)­CuIII(CF3)3 and CsF that produces chemo-, regio-, and stereoselectively (Z)-α-fluoro-β-CF3 styrenes. This method can be extended to achieve syn-oxy-trifluoromethylation and syn-aryl-trifluoromethylation of alkynes using phenoxides, alkoxides, or phenylboronic acid in place of CsF. It opens up new opportunities for preparing various functionalized trifluoromethylated Z-alkenes and demonstrates the potential of Cu­(III)–CF3 complexes in organic synthesis. %I ACS Publications