Facile Synthesis of Sulfobetaine-Stabilized Cu<sub>2</sub>O Nanoparticles and Their Biomedical Potential Marta J. Woźniak-Budych Łucja Przysiecka Barbara M. Maciejewska Daria Wieczorek Katarzyna Staszak Marcin Jarek Teofil Jesionowski Stefan Jurga 10.1021/acsbiomaterials.7b00465.s001 https://acs.figshare.com/articles/journal_contribution/Facile_Synthesis_of_Sulfobetaine-Stabilized_Cu_sub_2_sub_O_Nanoparticles_and_Their_Biomedical_Potential/5576113 A novel approach using a zwitterionic sulfobetaine-based surfactant for the synthesis of spherical copper oxide nanoparticles (Cu<sub>2</sub>O NPs) has been applied. For the first time, N-hexadecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate has been used as stabilizer to control the size and morphology of Cu<sub>2</sub>O NPs. Several techniques, such as transmission electron microscopy (TEM), X-ray diffraction (XRD), and fluorescence spectroscopy, are used to investigate the size, structure, and optical properties of synthesized Cu<sub>2</sub>O nanocrystals. The results indicate that copper­(I) oxide nanoparticles with size in the range of 2 to 45 nm and crystalline structure, exhibit intense yellow fluorescence (λ<sub>em</sub> = 575 nm). Furthermore, the cytotoxicity studies show that sulfobetaine-stabilized copper oxide nanoparticles prompt inhibition of cancer cell proliferation in a concentration-dependent manner, however, the adverse effect on the normal cells has also been observed. The results indicate that the sulfobetaine-stabilized Cu<sub>2</sub>O, because of their unique properties, have a potential to be applied in medical fields, such as cancer therapy and bioimaging. 2017-10-25 00:00:00 concentration-dependent manner novel approach sulfobetaine-stabilized copper oxide nanoparticles copper oxide nanoparticles TEM cancer therapy Cu 2 O nanocrystals cancer cell proliferation transmission electron microscopy cytotoxicity studies show Facile Synthesis XRD sulfobetaine-stabilized Cu 2 O fluorescence spectroscopy Several techniques 45 nm Sulfobetaine-Stabilized Cu 2 O Nanoparticles 575 nm Cu 2 O NPs zwitterionic sulfobetaine-based surfactant