Facile Synthesis of Sulfobetaine-Stabilized Cu<sub>2</sub>O Nanoparticles and Their Biomedical Potential
Marta J. Woźniak-Budych
Łucja Przysiecka
Barbara M. Maciejewska
Daria Wieczorek
Katarzyna Staszak
Marcin Jarek
Teofil Jesionowski
Stefan Jurga
10.1021/acsbiomaterials.7b00465.s001
https://acs.figshare.com/articles/journal_contribution/Facile_Synthesis_of_Sulfobetaine-Stabilized_Cu_sub_2_sub_O_Nanoparticles_and_Their_Biomedical_Potential/5576113
A novel
approach using a zwitterionic sulfobetaine-based surfactant
for the synthesis of spherical copper oxide nanoparticles (Cu<sub>2</sub>O NPs) has been applied. For the first time, N-hexadecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate
has been used as stabilizer to control the size and morphology of
Cu<sub>2</sub>O NPs. Several techniques, such as transmission electron
microscopy (TEM), X-ray diffraction (XRD), and fluorescence spectroscopy,
are used to investigate the size, structure, and optical properties
of synthesized Cu<sub>2</sub>O nanocrystals. The results indicate
that copper(I) oxide nanoparticles with size in the range of 2 to
45 nm and crystalline structure, exhibit intense yellow fluorescence
(λ<sub>em</sub> = 575 nm). Furthermore, the cytotoxicity studies
show that sulfobetaine-stabilized copper oxide nanoparticles prompt
inhibition of cancer cell proliferation in a concentration-dependent
manner, however, the adverse effect on the normal cells has also been
observed. The results indicate that the sulfobetaine-stabilized Cu<sub>2</sub>O, because of their unique properties, have a potential to
be applied in medical fields, such as cancer therapy and bioimaging.
2017-10-25 00:00:00
concentration-dependent manner
novel approach
sulfobetaine-stabilized copper oxide nanoparticles
copper oxide nanoparticles
TEM
cancer therapy
Cu 2 O nanocrystals
cancer cell proliferation
transmission electron microscopy
cytotoxicity studies show
Facile Synthesis
XRD
sulfobetaine-stabilized Cu 2 O
fluorescence spectroscopy
Several techniques
45 nm
Sulfobetaine-Stabilized Cu 2 O Nanoparticles
575 nm
Cu 2 O NPs
zwitterionic sulfobetaine-based surfactant