10.1021/acsbiomaterials.7b00465.s001 Marta J. Woźniak-Budych Marta J. Woźniak-Budych Łucja Przysiecka Łucja Przysiecka Barbara M. Maciejewska Barbara M. Maciejewska Daria Wieczorek Daria Wieczorek Katarzyna Staszak Katarzyna Staszak Marcin Jarek Marcin Jarek Teofil Jesionowski Teofil Jesionowski Stefan Jurga Stefan Jurga Facile Synthesis of Sulfobetaine-Stabilized Cu<sub>2</sub>O Nanoparticles and Their Biomedical Potential American Chemical Society 2017 concentration-dependent manner novel approach sulfobetaine-stabilized copper oxide nanoparticles copper oxide nanoparticles TEM cancer therapy Cu 2 O nanocrystals cancer cell proliferation transmission electron microscopy cytotoxicity studies show Facile Synthesis XRD sulfobetaine-stabilized Cu 2 O fluorescence spectroscopy Several techniques 45 nm Sulfobetaine-Stabilized Cu 2 O Nanoparticles 575 nm Cu 2 O NPs zwitterionic sulfobetaine-based surfactant 2017-10-25 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Facile_Synthesis_of_Sulfobetaine-Stabilized_Cu_sub_2_sub_O_Nanoparticles_and_Their_Biomedical_Potential/5576113 A novel approach using a zwitterionic sulfobetaine-based surfactant for the synthesis of spherical copper oxide nanoparticles (Cu<sub>2</sub>O NPs) has been applied. For the first time, N-hexadecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate has been used as stabilizer to control the size and morphology of Cu<sub>2</sub>O NPs. Several techniques, such as transmission electron microscopy (TEM), X-ray diffraction (XRD), and fluorescence spectroscopy, are used to investigate the size, structure, and optical properties of synthesized Cu<sub>2</sub>O nanocrystals. The results indicate that copper­(I) oxide nanoparticles with size in the range of 2 to 45 nm and crystalline structure, exhibit intense yellow fluorescence (λ<sub>em</sub> = 575 nm). Furthermore, the cytotoxicity studies show that sulfobetaine-stabilized copper oxide nanoparticles prompt inhibition of cancer cell proliferation in a concentration-dependent manner, however, the adverse effect on the normal cells has also been observed. The results indicate that the sulfobetaine-stabilized Cu<sub>2</sub>O, because of their unique properties, have a potential to be applied in medical fields, such as cancer therapy and bioimaging.