10.1021/acsbiomaterials.7b00465.s001
Marta J. Woźniak-Budych
Marta J.
Woźniak-Budych
Łucja Przysiecka
Łucja
Przysiecka
Barbara M. Maciejewska
Barbara M.
Maciejewska
Daria Wieczorek
Daria
Wieczorek
Katarzyna Staszak
Katarzyna
Staszak
Marcin Jarek
Marcin
Jarek
Teofil Jesionowski
Teofil
Jesionowski
Stefan Jurga
Stefan
Jurga
Facile Synthesis of Sulfobetaine-Stabilized Cu<sub>2</sub>O Nanoparticles and Their Biomedical Potential
American Chemical Society
2017
concentration-dependent manner
novel approach
sulfobetaine-stabilized copper oxide nanoparticles
copper oxide nanoparticles
TEM
cancer therapy
Cu 2 O nanocrystals
cancer cell proliferation
transmission electron microscopy
cytotoxicity studies show
Facile Synthesis
XRD
sulfobetaine-stabilized Cu 2 O
fluorescence spectroscopy
Several techniques
45 nm
Sulfobetaine-Stabilized Cu 2 O Nanoparticles
575 nm
Cu 2 O NPs
zwitterionic sulfobetaine-based surfactant
2017-10-25 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Facile_Synthesis_of_Sulfobetaine-Stabilized_Cu_sub_2_sub_O_Nanoparticles_and_Their_Biomedical_Potential/5576113
A novel
approach using a zwitterionic sulfobetaine-based surfactant
for the synthesis of spherical copper oxide nanoparticles (Cu<sub>2</sub>O NPs) has been applied. For the first time, N-hexadecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate
has been used as stabilizer to control the size and morphology of
Cu<sub>2</sub>O NPs. Several techniques, such as transmission electron
microscopy (TEM), X-ray diffraction (XRD), and fluorescence spectroscopy,
are used to investigate the size, structure, and optical properties
of synthesized Cu<sub>2</sub>O nanocrystals. The results indicate
that copper(I) oxide nanoparticles with size in the range of 2 to
45 nm and crystalline structure, exhibit intense yellow fluorescence
(λ<sub>em</sub> = 575 nm). Furthermore, the cytotoxicity studies
show that sulfobetaine-stabilized copper oxide nanoparticles prompt
inhibition of cancer cell proliferation in a concentration-dependent
manner, however, the adverse effect on the normal cells has also been
observed. The results indicate that the sulfobetaine-stabilized Cu<sub>2</sub>O, because of their unique properties, have a potential to
be applied in medical fields, such as cancer therapy and bioimaging.