10.1021/acs.cgd.7b01096.s001
Maximilian
O. Besenhard
Maximilian
O.
Besenhard
Peter Neugebauer
Peter
Neugebauer
Otto Scheibelhofer
Otto
Scheibelhofer
Johannes G. Khinast
Johannes G.
Khinast
Crystal Engineering in Continuous Plug-Flow Crystallizers
American Chemical Society
2017
crystal properties
plug flow characteristics
polymorphic composition
Controlled crystal growth
Continuous Plug-Flow Crystallizers Size
particle transport
process parameters
crystal Engineering
shape distribution
temperature cycling
tubing diameter
crystal size
polymorphic form
crystal engineering
Tubular crystallizers
flow rates
2017-10-10 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Crystal_Engineering_in_Continuous_Plug-Flow_Crystallizers/5559331
Size,
shape, and polymorphic form are the critical attributes of
crystalline particles and represent the major focus of today’s
crystallization process design. This work demonstrates how crystal
properties can be tuned efficiently in solution via a tubular crystallizer
that facilitates rapid temperature cycling. Controlled crystal growth,
dissolution, and secondary nucleation allow a precise control of the
crystal size and shape distribution, as well as polymorphic composition.
Tubular crystallizers utilizing segmented flow such as the one presented
in our work can provide plug flow characteristics, fast heating and
cooling, allowing for rapid changes of the supersaturation. This makes
them superior for crystal engineering over common crystallizers. Characterization
of particle transport, however, revealed that careful selection of
process parameters, such as tubing diameter, flow rates, solvents,
etc., is crucial to achieve the full benefits of such reactors.