10.1021/acs.orglett.7b02841.s001 Qing-Lan Pei Qing-Lan Pei Guan-Da Che Guan-Da Che Ru-Yi Zhu Ru-Yi Zhu Jian He Jian He Jin-Quan Yu Jin-Quan Yu An Epoxide-Mediated Deprotection Method for Acidic Amide Auxiliary American Chemical Society 2017 acidic amide Acidic Amide Auxiliary removal Epoxide-Mediated Deprotection Method Facile alcoholysis amide substrates 2017-10-17 16:21:09 Journal contribution https://acs.figshare.com/articles/journal_contribution/An_Epoxide-Mediated_Deprotection_Method_for_Acidic_Amide_Auxiliary/5505820 A practical method for the removal of a versatile acidic amide auxiliary has been developed. Facile alcoholysis of the amide in the presence of KOAc is enabled by an epoxide, which mechanistically resembles the removal of the Myers’ auxiliary. The protocol has been applied to the removal of a variety of amide substrates and their C–H functionalization products with high efficiency and low cost, representing a step forward toward the development of a versatile directing group for C–H activation.