10.1021/acs.inorgchem.7b02212.s001
Anastasiya O. Solovieva
Anastasiya O.
Solovieva
Kaplan Kirakci
Kaplan
Kirakci
Anton A. Ivanov
Anton
A. Ivanov
Pavel Kubát
Pavel
Kubát
Tatiana N. Pozmogova
Tatiana N.
Pozmogova
Svetlana M. Miroshnichenko
Svetlana M.
Miroshnichenko
Elena V. Vorontsova
Elena V.
Vorontsova
Anton V. Chechushkov
Anton V.
Chechushkov
Kristina E. Trifonova
Kristina E.
Trifonova
Maria S. Fufaeva
Maria S.
Fufaeva
Evgeniy I. Kretov
Evgeniy I.
Kretov
Yuri V. Mironov
Yuri V.
Mironov
Alexander F. Poveshchenko
Alexander F.
Poveshchenko
Kamil Lang
Kamil
Lang
Michael A. Shestopalov
Michael A.
Shestopalov
Singlet Oxygen Production and Biological Activity
of Hexanuclear Chalcocyanide Rhenium Cluster Complexes [{Re<sub>6</sub>Q<sub>8</sub>}(CN)<sub>6</sub>]<sup>4–</sup> (Q = S, Se, Te)
American Chemical Society
2017
Re
photodynamic cytotoxicity
term
singlet oxygen productivity
singlet oxygen photogeneration
blue-light photodynamic therapy
blue-light PDT
building blocks
singlet oxygen generation ability
Singlet Oxygen Production
photoinduced cytotoxicity
CN
photoinduced cytotoxic effect
uptake kinetics
Se
photoinduced oxidative stress
Te
Biological Activity
Octahedral rhenium cluster complexes
singlet oxygen photosensitizing materials
2017-10-08 16:29:33
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Singlet_Oxygen_Production_and_Biological_Activity_of_Hexanuclear_Chalcocyanide_Rhenium_Cluster_Complexes_Re_sub_6_sub_Q_sub_8_sub_CN_sub_6_sub_sup_4_sup_Q_S_Se_Te_/5480491
Octahedral rhenium cluster complexes
have recently emerged as relevant building blocks for the design of
singlet oxygen photosensitizing materials toward biological applications
such as blue-light photodynamic therapy. However, their singlet oxygen
generation ability as well as biological properties have been studied
only superficially. Herein we investigate in detail the singlet oxygen
photogeneration, dark and photoinduced cytotoxicity, cellular uptake
kinetics, cellular localization and in vitro photoinduced oxidative
stress, and photodynamic cytotoxicity of the series of octahedral
rhenium cluster complexes [{Re<sub>6</sub>Q<sub>8</sub>}(CN)<sub>6</sub>]<sup>4–</sup>, where Q = S, Se, Te. Our results demonstrate
that the selenium-containing complex possesses optimal properties
in terms of absorption and singlet oxygen productivity. These features
coupled with the cellular internalization and low dark toxicity lead
to the first photoinduced cytotoxic effect observed for a molecular
[{M<sub>6</sub>Q<sub>8</sub>}L<sub>6</sub>] complex, making it a promising
object for further study in terms of blue-light PDT.