10.1021/acs.inorgchem.7b02212.s001 Anastasiya O. Solovieva Anastasiya O. Solovieva Kaplan Kirakci Kaplan Kirakci Anton A. Ivanov Anton A. Ivanov Pavel Kubát Pavel Kubát Tatiana N. Pozmogova Tatiana N. Pozmogova Svetlana M. Miroshnichenko Svetlana M. Miroshnichenko Elena V. Vorontsova Elena V. Vorontsova Anton V. Chechushkov Anton V. Chechushkov Kristina E. Trifonova Kristina E. Trifonova Maria S. Fufaeva Maria S. Fufaeva Evgeniy I. Kretov Evgeniy I. Kretov Yuri V. Mironov Yuri V. Mironov Alexander F. Poveshchenko Alexander F. Poveshchenko Kamil Lang Kamil Lang Michael A. Shestopalov Michael A. Shestopalov Singlet Oxygen Production and Biological Activity of Hexanuclear Chalcocyanide Rhenium Cluster Complexes [{Re<sub>6</sub>Q<sub>8</sub>}(CN)<sub>6</sub>]<sup>4–</sup> (Q = S, Se, Te) American Chemical Society 2017 Re photodynamic cytotoxicity term singlet oxygen productivity singlet oxygen photogeneration blue-light photodynamic therapy blue-light PDT building blocks singlet oxygen generation ability Singlet Oxygen Production photoinduced cytotoxicity CN photoinduced cytotoxic effect uptake kinetics Se photoinduced oxidative stress Te Biological Activity Octahedral rhenium cluster complexes singlet oxygen photosensitizing materials 2017-10-08 16:29:33 Journal contribution https://acs.figshare.com/articles/journal_contribution/Singlet_Oxygen_Production_and_Biological_Activity_of_Hexanuclear_Chalcocyanide_Rhenium_Cluster_Complexes_Re_sub_6_sub_Q_sub_8_sub_CN_sub_6_sub_sup_4_sup_Q_S_Se_Te_/5480491 Octahedral rhenium cluster complexes have recently emerged as relevant building blocks for the design of singlet oxygen photosensitizing materials toward biological applications such as blue-light photodynamic therapy. However, their singlet oxygen generation ability as well as biological properties have been studied only superficially. Herein we investigate in detail the singlet oxygen photogeneration, dark and photoinduced cytotoxicity, cellular uptake kinetics, cellular localization and in vitro photoinduced oxidative stress, and photodynamic cytotoxicity of the series of octahedral rhenium cluster complexes [{Re<sub>6</sub>Q<sub>8</sub>}­(CN)<sub>6</sub>]<sup>4–</sup>, where Q = S, Se, Te. Our results demonstrate that the selenium-containing complex possesses optimal properties in terms of absorption and singlet oxygen productivity. These features coupled with the cellular internalization and low dark toxicity lead to the first photoinduced cytotoxic effect observed for a molecular [{M<sub>6</sub>Q<sub>8</sub>}­L<sub>6</sub>] complex, making it a promising object for further study in terms of blue-light PDT.