Tabercorymines A and B, Two Vobasinyl–Ibogan-Type
Bisindole Alkaloids from Tabernaemontana corymbosa
Yu-Xi Yuan
Yu Zhang
Ling-Li Guo
Yue-Hu Wang
Masuo Goto
Susan L. Morris-Natschke
Kuo-Hsiung Lee
Xiao-Jiang Hao
10.1021/acs.orglett.7b02445.s002
https://acs.figshare.com/articles/dataset/Tabercorymines_A_and_B_Two_Vobasinyl_Ibogan-Type_Bisindole_Alkaloids_from_Tabernaemontana_corymbosa/5379673
Tabercorymines A
(<b>1</b>) and B (<b>2</b>), two new
vobasinyl–ibogan-type bisindole alkaloids with an unprecedented
skeleton, were isolated from Tabernaemontana corymbosa. Their structures were established by a combination of spectroscopic
data, chemical transformation, single-crystal X-ray diffraction, and
ECD calculation. Compound <b>1</b> represents a novel bisindole
alkaloid, characterized by a caged heteropentacyclic ring system incorporating
an unprecedented C-7/C-20 bond in the vobasinyl unit. Alkaloids <b>1</b> and <b>2</b> showed potent antiproliferative activity
against several human cancer cell lines, including vincristine-resistant
KB.
2017-09-06 14:51:15
novel bisindole alkaloid
cancer cell lines
skeleton
Vobasinyl
Compound 1
alkaloids
spectroscopic data
combination
chemical transformation
Alkaloids 1
vincristine-resistant KB
ECD calculation
Tabernaemontana corymbosa Tabercorymines
antiproliferative activity
Bisindole
Tabernaemontana corymbosa
vobasinyl unit
bond
heteropentacyclic ring system
single-crystal X-ray diffraction