10.1021/acs.orglett.7b01863.s001
Junfei Zhou
Junfei
Zhou
Guanqun Zhan
Guanqun
Zhan
Hanqi Zhang
Hanqi
Zhang
Qihua Zhang
Qihua
Zhang
Ying Li
Ying
Li
Yongbo Xue
Yongbo
Xue
Guangmin Yao
Guangmin
Yao
Rhodomollanol A, a Highly Oxygenated Diterpenoid with
a 5/7/5/5 Tetracyclic Carbon Skeleton from the Leaves of <i>Rhododendron
molle</i>
American Chemical Society
2017
Compound 1
ci
1B
Rhododendron molle
XXXI
PTP
diterpenoid
tran
single-crystal X-ray diffraction
2017-07-13 12:23:07
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Rhodomollanol_A_a_Highly_Oxygenated_Diterpenoid_with_a_5_7_5_5_Tetracyclic_Carbon_Skeleton_from_the_Leaves_of_i_Rhododendron_molle_i_/5203567
A novel
diterpenoid with an unprecedented carbon skeleton, rhodomollanol
A (<b>1</b>), and a new grayanane diterpenoid, rhodomollein
XXXI (<b>2</b>), were isolated from the leaves of <i>Rhododendron
molle</i>. Their structures were elucidated using comprehensive
spectroscopic methods and single-crystal X-ray diffraction. Compound <b>1</b> possesses a unique <i>cis</i>/<i>trans</i>/<i>trans</i>/<i>cis</i>/<i>cis</i>-fused 3/5/7/5/5/5 hexacyclic ring system featuring a rare 7-oxabicyclo[4.2.1]nonane
core decorated with three cyclopentane units. The plausible biosynthetic
pathway for <b>1</b> was proposed. Compound <b>1</b> exhibited
moderate PTP1B inhibitory activity.