Kinetic Modeling of the Nickel-Catalyzed Esterification
of Amides
Nicholas
A. Weires
Daniel D. Caspi
Neil K. Garg
10.1021/acscatal.7b01444.s001
https://acs.figshare.com/articles/journal_contribution/Kinetic_Modeling_of_the_Nickel-Catalyzed_Esterification_of_Amides/5072152
Nickel-catalyzed
coupling reactions provide exciting tools in chemical
synthesis. However, most methodologies in this area require high catalyst
loadings, which commonly range from 10–20 mol % nickel.
Through an academic-industrial collaboration, we demonstrate that
kinetic modeling can be used strategically to overcome this problem,
specifically within the context of the Ni-catalyzed conversion of
amides to esters. The successful application of this methodology to
a multigram-scale coupling, using only 0.4 mol % Ni, highlights
the impact of this endeavor.
2017-05-22 00:00:00
esters
0.4
Kinetic Modeling
endeavor
chemical synthesis
impact
application
methodology
Ni-catalyzed conversion
tool
Nickel-Catalyzed Esterification
catalyst loadings
mol
modeling
problem
multigram-scale
amide
academic-industrial collaboration
context
Amides Nickel-catalyzed