Kinetic Modeling of the Nickel-Catalyzed Esterification of Amides Nicholas A. Weires Daniel D. Caspi Neil K. Garg 10.1021/acscatal.7b01444.s001 https://acs.figshare.com/articles/journal_contribution/Kinetic_Modeling_of_the_Nickel-Catalyzed_Esterification_of_Amides/5072152 Nickel-catalyzed coupling reactions provide exciting tools in chemical synthesis. However, most methodologies in this area require high catalyst loadings, which commonly range from 10–20 mol % nickel. Through an academic-industrial collaboration, we demonstrate that kinetic modeling can be used strategically to overcome this problem, specifically within the context of the Ni-catalyzed conversion of amides to esters. The successful application of this methodology to a multigram-scale coupling, using only 0.4 mol % Ni, highlights the impact of this endeavor. 2017-05-22 00:00:00 esters 0.4 Kinetic Modeling endeavor chemical synthesis impact application methodology Ni-catalyzed conversion tool Nickel-Catalyzed Esterification catalyst loadings mol modeling problem multigram-scale amide academic-industrial collaboration context Amides Nickel-catalyzed