%0 Journal Article
%A Gui, Chun
%A Zhang, Shanwen
%A Zhu, Xiangcheng
%A Ding, Wenjuan
%A Huang, Hongbo
%A Gu, Yu-Cheng
%A Duan, Yanwen
%A Ju, Jianhua
%D 2017
%T Antimicrobial Spirotetronate Metabolites from Marine-Derived Micromonospora harpali SCSIO GJ089
%U https://acs.figshare.com/articles/journal_contribution/Antimicrobial_Spirotetronate_Metabolites_from_Marine-Derived_i_Micromonospora_harpali_i_SCSIO_GJ089/4991057
%R 10.1021/acs.jnatprod.7b00176.s001
%2 https://acs.figshare.com/ndownloader/files/8404067
%K spirotetronate glycosides
%K B . subtilis BS 01
%K bacteria Bacillus
%K Antimicrobial Spirotetronate Metabolites
%K carbonyl moiety
%K spirotetronate skeletons
%K . subtili
%K BT 01
%K MS spectroscopic data
%K 2 D NMR
%K Marine-Derived Micromonospora harpali SCSIO GJ 089
%K 1 D
%K 8- hydroxy -22-dehydroxy
%K marine-derived Micromonospora harpali SCSIO GJ 089.
%K AC 6H
%K spirotetronate aglycones
%K tetrocarcin P
%K MIC values
%X Two new spirotetronate aglycones,
22-dehydroxymethyl-kijanolide
(1) and 8-hydroxy-22-dehydroxymethyl-kijanolide (2), along
with seven new spirotetronate glycosides, microsporanates A–F
(3–8) and tetrocarcin P (9), together with three known tetrocarcins [tetrocarcins A (10), B (11), and AC6H (12)], were
isolated from fermentation broths of the marine-derived Micromonospora
harpali SCSIO GJ089. The structures of 1–9 were elucidated on the basis of 1D and 2D NMR and MS spectroscopic
data. Compounds 3–8 feature an α,β-unsaturated
carbonyl moiety within their spirotetronate skeletons. Moreover, compounds 3–12 displayed strong to moderate antibacterial
activities against Gram positive bacteria Bacillus thuringiensis BT01 and B. subtilis BS01 with MIC values
ranging from 0.016 to 8.0 μg/mL.
%I ACS Publications