Tumor Acidity/NIR Controlled Interaction of Transformable
Nanoparticle with Biological Systems for Cancer Therapy
Dongdong Li
Yinchu Ma
Jinzhi Du
Wei Tao
Xiaojiao Du
Xianzhu Yang
Jun Wang
10.1021/acs.nanolett.6b05396.s001
https://acs.figshare.com/articles/journal_contribution/Tumor_Acidity_NIR_Controlled_Interaction_of_Transformable_Nanoparticle_with_Biological_Systems_for_Cancer_Therapy/4863284
Precisely controlling
the interaction of nanoparticles with biological systems (nanobio
interactions) from the injection site to biological targets shows
great potential for biomedical applications. Inspired by the ability
of nanoparticles to alter their physicochemical properties according
to different stimuli, we explored the tumor acidity and near-infrared
(NIR) light activated transformable nanoparticle <sup>DA</sup>TAT-NP<sub>IR&DOX</sub>. This nanoparticle consists of a tumor acidity-activated
TAT [the TAT lysine residues’ amines was modified with 2,3-dimethylmaleic
anhydride (DA)], a flexible chain polyphosphoester core coencapsulated
a NIR dye IR-780, and DOX (doxorubicin). The physicochemical properties
of the nanoparticle can be controlled in a stepwise fashion using
tumor acidity and NIR light, resulting in adjustable nanobio interactions.
The resulting transformable nanoparticle <sup>DA</sup>TAT-NP<sub>IR&DOX</sub> efficiently avoids the interaction with mononuclear phagocyte system
(MPS) (“stealth” state) due to the masking of the TAT
peptide during blood circulation. Once it has accumulated in the tumor
tissues, <sup>DA</sup>TAT-NP<sub>IR&DOX</sub> is reactivated by
tumor acidity and transformed into the “recognize” state
in order to promote interaction with tumor cells and enhance cellular
internalization. Then, this nanoparticle is transformed into “attack”
state under NIR irradiation, achieving the supersensitive DOX release
from the flexible chain polyphosphoester core in order to increase
the DOX–DNA interaction. This concept provides new avenues
for the creation of transformable drug delivery systems that have
the ability to control nanobio interactions.
2017-04-04 00:00:00
nanoparticle
NIR
transformable drug delivery systems
tumor acidity
tumor acidity-activated TAT
MPS
TAT-NP
DOX
chain polyphosphoester core coencapsulated
nanobio interactions
DA
physicochemical properties
control nanobio interactions
IR
chain polyphosphoester core