%0 Journal Article
%A Wang, Shanshan
%A Zeman, Charles J.
%A Jiang, Junlin
%A Pan, Zhenxing
%A Schanze, Kirk S.
%D 2017
%T Intercalation
of Alkynylplatinum(II) Terpyridine Complexes
into a Helical Poly(phenylene ethynylene) Sulfonate: Application to
Protein Sensing
%U https://acs.figshare.com/articles/journal_contribution/Intercalation_of_Alkynylplatinum_II_Terpyridine_Complexes_into_a_Helical_Poly_phenylene_ethynylene_Sulfonate_Application_to_Protein_Sensing/4854662
%R 10.1021/acsami.7b01587.s001
%2 https://acs.figshare.com/ndownloader/files/8048096
%K PPESO
%K sulfonate-conjugated polyelectrolytes
%K Pt
%K polymer helix
%K 3 MMLCT
%K 3 MMLCT state emission
%K state emission
%K protein
%K complex
%K ensemble
%K fluorescence
%X The
interactions of two anionic poly(phenylene ethynylene) sulfonate-conjugated
polyelectrolytes (mPPESO3– and pPPESO3–) with
two alkynylplatinum(II) terpyridine complexes (Pt2+ and
Pt3+) were studied. The Pt(II) complexes interact with
helical mPPESO3– by
intercalation within the polymer helix to form a “guest–host”
ensemble. Titration of Pt(II) complexes into an aqueous solution of mPPESO3– gives rise to efficient
quenching of the polymer’s fluorescence; meanwhile, triplet
metal–metal-to-ligand charge transfer (3MMLCT) state
emission from the intercalated Pt(II) complexes appears when the ensembles
are excited into the polymer’s absorption band. The 3MMLCT state emission implies that the Pt(II) complexes aggregate
or dimerize on the mPPESO3– scaffold. The responses of the mPPESO3– and Pt(II) complex ensembles to various proteins
were examined by monitoring the mPPESO3– fluorescence change. Negatively charged proteins
recover the mPPESO3– fluorescence more than the positively charged proteins under physiological
pH, indicating that electrostatics play an important role in the protein–ensemble
interaction.
%I ACS Publications