%0 Journal Article
%A Wang, Chunxia
%A Zhang, Luoqiang
%A You, Jingsong
%D 2017
%T Nickel-Catalyzed Aminoxylation of Inert Aliphatic
C(sp3)–H Bonds with Stable Nitroxyl Radicals under
Air: One-Pot Route to α‑Formyl Acid Derivatives
%U https://acs.figshare.com/articles/journal_contribution/Nickel-Catalyzed_Aminoxylation_of_Inert_Aliphatic_C_sp_sup_3_sup_H_Bonds_with_Stable_Nitroxyl_Radicals_under_Air_One-Pot_Route_to_Formyl_Acid_Derivatives/4784491
%R 10.1021/acs.orglett.7b00479.s001
%2 https://acs.figshare.com/ndownloader/files/7860424
%K Stable Nitroxyl Radicals
%K evidence
%K α- formyl acid derivatives
%K Derivatives Nickel-catalyzed aminoxylation
%K Inert
%K one-pot approach
%K Nickel-Catalyzed Aminoxylation
%K alkoxyamine derivatives
%K oxidative addition
%K One-Pot Route
%K aminoxylation process
%K Formyl
%K nitroxyl
%K cyclometallic
%K Bond
%K unactivated
%K transition-metal-catalyzed functionalization
%K Aliphatic
%K reaction-mechanism study
%K bond
%X Nickel-catalyzed
aminoxylation of an unactivated C(sp3)–H bond with
a stable nitroxyl radical has been accomplished
for the first time to offer various N-alkoxyamine
derivatives, which further enables a one-pot approach to α-formyl
acid derivatives. The aminoxylation process reported also provides
direct evidence for the oxidative addition of a cyclometallic intermediate
with a free radical, which is helpful for the reaction-mechanism study
in transition-metal-catalyzed functionalization of inert C(sp3)–H bonds.
%I ACS Publications