10.1021/acs.orglett.7b00479.s001 Chunxia Wang Chunxia Wang Luoqiang Zhang Luoqiang Zhang Jingsong You Jingsong You Nickel-Catalyzed Aminoxylation of Inert Aliphatic C(sp<sup>3</sup>)–H Bonds with Stable Nitroxyl Radicals under Air: One-Pot Route to α‑Formyl Acid Derivatives American Chemical Society 2017 Stable Nitroxyl Radicals evidence α- formyl acid derivatives Derivatives Nickel-catalyzed aminoxylation Inert one-pot approach Nickel-Catalyzed Aminoxylation alkoxyamine derivatives oxidative addition One-Pot Route aminoxylation process Formyl nitroxyl cyclometallic Bond unactivated transition-metal-catalyzed functionalization Aliphatic reaction-mechanism study bond 2017-03-23 20:15:22 Journal contribution https://acs.figshare.com/articles/journal_contribution/Nickel-Catalyzed_Aminoxylation_of_Inert_Aliphatic_C_sp_sup_3_sup_H_Bonds_with_Stable_Nitroxyl_Radicals_under_Air_One-Pot_Route_to_Formyl_Acid_Derivatives/4784491 Nickel-catalyzed aminoxylation of an unactivated C­(sp<sup>3</sup>)–H bond with a stable nitroxyl radical has been accomplished for the first time to offer various <i>N</i>-alkoxyamine derivatives, which further enables a one-pot approach to α-formyl acid derivatives. The aminoxylation process reported also provides direct evidence for the oxidative addition of a cyclometallic intermediate with a free radical, which is helpful for the reaction-mechanism study in transition-metal-catalyzed functionalization of inert C­(sp<sup>3</sup>)–H bonds.