10.1021/acs.orglett.7b00479.s001
Chunxia Wang
Chunxia
Wang
Luoqiang Zhang
Luoqiang
Zhang
Jingsong You
Jingsong
You
Nickel-Catalyzed Aminoxylation of Inert Aliphatic
C(sp<sup>3</sup>)–H Bonds with Stable Nitroxyl Radicals under
Air: One-Pot Route to α‑Formyl Acid Derivatives
American Chemical Society
2017
Stable Nitroxyl Radicals
evidence
α- formyl acid derivatives
Derivatives Nickel-catalyzed aminoxylation
Inert
one-pot approach
Nickel-Catalyzed Aminoxylation
alkoxyamine derivatives
oxidative addition
One-Pot Route
aminoxylation process
Formyl
nitroxyl
cyclometallic
Bond
unactivated
transition-metal-catalyzed functionalization
Aliphatic
reaction-mechanism study
bond
2017-03-23 20:15:22
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Nickel-Catalyzed_Aminoxylation_of_Inert_Aliphatic_C_sp_sup_3_sup_H_Bonds_with_Stable_Nitroxyl_Radicals_under_Air_One-Pot_Route_to_Formyl_Acid_Derivatives/4784491
Nickel-catalyzed
aminoxylation of an unactivated C(sp<sup>3</sup>)–H bond with
a stable nitroxyl radical has been accomplished
for the first time to offer various <i>N</i>-alkoxyamine
derivatives, which further enables a one-pot approach to α-formyl
acid derivatives. The aminoxylation process reported also provides
direct evidence for the oxidative addition of a cyclometallic intermediate
with a free radical, which is helpful for the reaction-mechanism study
in transition-metal-catalyzed functionalization of inert C(sp<sup>3</sup>)–H bonds.