Zhao, Ren Lu, Wenjun Palladium-Catalyzed β‑Mesylation of Simple Amide via Primary sp<sup>3</sup> C–H Activation A β-mesylation of primary sp<sup>3</sup> C–H bonds from simple amides with methanesulfonic anhydride (Ms<sub>2</sub>O) has been established successfully at 80 °C in a Pd­(OAc)<sub>2</sub> (catalyst)/K<sub>2</sub>S<sub>2</sub>O<sub>8</sub> (oxidant)/CF<sub>3</sub>CH<sub>2</sub>OH (solvent) system. These amide substrates involve <i>N</i>-monosubstituted linear, branch, or cyclic alkanes, and electron-deficient benzyl compounds. The β-mesylated amide products can be converted easily to β-fluoroamides or β-lactams through inter- or intramolecular S<sub>N</sub>2 processes. intramolecular S N 2 processes;β- fluoroamides;methanesulfonic anhydride;CH;β- lactams;OH;cyclic alkanes;electron-deficient benzyl compounds;Simple Amide;sp;amide substrates;β- mesylation;Ms 2 O;β- mesylated amide products 2017-03-22
    https://acs.figshare.com/articles/journal_contribution/Palladium-Catalyzed_Mesylation_of_Simple_Amide_via_Primary_sp_sup_3_sup_C_H_Activation/4776553
10.1021/acs.orglett.7b00536.s001