%0 Generic %A Wang, Chunyu %A Wang, Zhonglei %A Xie, Xiaoni %A Yao, Xiaotong %A Li, Guang %A Zu, Liansuo %D 2017 %T Total Synthesis of (±)-Grandilodine B %U https://acs.figshare.com/articles/dataset/Total_Synthesis_of_-Grandilodine_B/4753798 %R 10.1021/acs.orglett.7b00591.s003 %2 https://acs.figshare.com/ndownloader/files/7796815 %K Grandilodine %K diastereoselective cyanation %K stereocenter %K opened-type Kopsia alkaloid grandilodine B %K stereoselectively %K cycloaddition %K Diel %K dipolar %K synthesis %K facial-selective %K nitrone %K Total Synthesis %K quaternary %X The first total synthesis of the opened-type Kopsia alkaloid grandilodine B is reported. Four stereocenters of this alkaloid, three of them quaternary, are stereoselectively generated by a Diels–Alder reaction, a diastereoselective cyanation of tertiary alcohol, and a facial-selective nitrone 1,3-dipolar cycloaddition. %I ACS Publications