Transition-Metal-Free Oxidative Decarboxylative Cross Coupling of α,β-Unsaturated Carboxylic Acids with Cyclic Ethers under Air Conditions: Mild Synthesis of α‑Oxyalkyl Ketones Peng-Yi Ji Yu-Feng Liu Jing-Wen Xu Wei-Ping Luo Qiang Liu Can-Cheng Guo 10.1021/acs.joc.6b02993.s001 https://acs.figshare.com/articles/journal_contribution/Transition-Metal-Free_Oxidative_Decarboxylative_Cross_Coupling_of_-Unsaturated_Carboxylic_Acids_with_Cyclic_Ethers_under_Air_Conditions_Mild_Synthesis_of_Oxyalkyl_Ketones/4702783 A novel K<sub>2</sub>S<sub>2</sub>O<sub>8</sub>-promoted decarboxylative cross coupling of α,β-unsaturated carboxylic acids with cyclic ethers was developed under aerobic conditions. The present protocol, which includes C–C and CO bond formation in one step through addition, oxidation, and decarboxylation processes, leads to the desired ketone products in moderate to excellent yields. In addition, mechanism studies showed that the transformation process undergoes a radical pathway via a direct activation of the α-sp<sup>3</sup> C–H bond of oxygen of the cyclic ether. 2017-02-22 00:00:00 Transition-Metal-Free Oxidative Decarboxylative Cross Cyclic Ethers cyclic ethers Oxyalkyl carboxylic acids novel K 2 S 2 O 8 Mild Synthesis activation ketone products oxidation Ketone transformation process decarboxylative decarboxylation processes α- sp Carboxylic yield Unsaturated cyclic ether Air Conditions mechanism studies pathway Acid bond