Formal Synthesis of (±)-Aplykurodinone‑1 through a Hetero-Pauson–Khand Cycloaddition Approach Cheng Tao Jing Zhang Xiaoming Chen Huifei Wang Yun Li Bin Cheng Hongbin Zhai 10.1021/acs.orglett.7b00068.s002 https://acs.figshare.com/articles/dataset/Formal_Synthesis_of_-Aplykurodinone_1_through_a_Hetero-Pauson_Khand_Cycloaddition_Approach/4669057 The tricyclic intermediate <b>2</b> has been synthesized in eight steps from known compound <b>6</b> in 20% overall yield. As such, this constitutes a highly efficient formal synthesis of (±)-aplykurodinone-1. This synthesis features a unique, one-pot, intramolecular hetero-Pauson-Khand reaction (<i>h</i>-PKR)/desilylation sequence to expeditiously construct the tricyclic framework, providing valuable insights for expanding the scope and boundaries of <i>h</i>-PKR. 2017-02-20 20:50:12 intramolecular hetero-Pauson-Khand reaction sequence compound 6 tricyclic framework Approach PKR Formal Synthesis Aplykurodinone scope insight synthesis features -1. one-pot Hetero-Pauson aplykurodinone Cycloaddition