10.1021/acs.orglett.7b00068.s002 Cheng Tao Cheng Tao Jing Zhang Jing Zhang Xiaoming Chen Xiaoming Chen Huifei Wang Huifei Wang Yun Li Yun Li Bin Cheng Bin Cheng Hongbin Zhai Hongbin Zhai Formal Synthesis of (±)-Aplykurodinone‑1 through a Hetero-Pauson–Khand Cycloaddition Approach American Chemical Society 2017 intramolecular hetero-Pauson-Khand reaction sequence compound 6 tricyclic framework Approach PKR Formal Synthesis Aplykurodinone scope insight synthesis features -1. one-pot Hetero-Pauson aplykurodinone Cycloaddition 2017-02-20 20:50:12 Dataset https://acs.figshare.com/articles/dataset/Formal_Synthesis_of_-Aplykurodinone_1_through_a_Hetero-Pauson_Khand_Cycloaddition_Approach/4669057 The tricyclic intermediate <b>2</b> has been synthesized in eight steps from known compound <b>6</b> in 20% overall yield. As such, this constitutes a highly efficient formal synthesis of (±)-aplykurodinone-1. This synthesis features a unique, one-pot, intramolecular hetero-Pauson-Khand reaction (<i>h</i>-PKR)/desilylation sequence to expeditiously construct the tricyclic framework, providing valuable insights for expanding the scope and boundaries of <i>h</i>-PKR.