10.1021/acs.orglett.7b00068.s002
Cheng Tao
Cheng
Tao
Jing Zhang
Jing
Zhang
Xiaoming Chen
Xiaoming
Chen
Huifei Wang
Huifei
Wang
Yun Li
Yun
Li
Bin Cheng
Bin
Cheng
Hongbin Zhai
Hongbin
Zhai
Formal Synthesis of (±)-Aplykurodinone‑1
through a Hetero-Pauson–Khand Cycloaddition Approach
American Chemical Society
2017
intramolecular hetero-Pauson-Khand reaction
sequence
compound 6
tricyclic framework
Approach
PKR
Formal Synthesis
Aplykurodinone
scope
insight
synthesis features
-1.
one-pot
Hetero-Pauson
aplykurodinone
Cycloaddition
2017-02-20 20:50:12
Dataset
https://acs.figshare.com/articles/dataset/Formal_Synthesis_of_-Aplykurodinone_1_through_a_Hetero-Pauson_Khand_Cycloaddition_Approach/4669057
The
tricyclic intermediate <b>2</b> has been synthesized
in eight steps from known compound <b>6</b> in 20% overall yield.
As such, this constitutes a highly efficient formal synthesis of (±)-aplykurodinone-1.
This synthesis features a unique, one-pot, intramolecular hetero-Pauson-Khand
reaction (<i>h</i>-PKR)/desilylation sequence to expeditiously
construct the tricyclic framework, providing valuable insights for
expanding the scope and boundaries of <i>h</i>-PKR.