Pd<sup>II</sup>/Ag<sup>I</sup>‑Catalyzed Room-Temperature Reaction of γ‑Hydroxy Lactams: Mechanism, Scope, and Antistaphylococcal Activity DuttaManali M. MandalSanti PeguRupa PratiharSanjay 2017 The present work reports a Pd<sup>II</sup>/Ag<sup>I</sup>-promoted amidoalkylation reaction involving various γ-hydroxy lactams and C/O/S nucleophiles at room temperature. The dual mode of activation of both the electrophile and nucleophile by in situ generated catalytically active cationic Pd<sup>II</sup> species facilitates the reaction at room temperature. Among the synthesized isoindoline derivatives, three compounds are found to be active against vancomycin and methicillin-resistant <i>S. aureus</i> strain with appreciable MIC values.