Enantioselective
Synthesis of [6]Carbohelicenes
Elisa González-Fernández
Leo D. M. Nicholls
Lukas D. Schaaf
Christophe Farès
Christian W. Lehmann
Manuel Alcarazo
10.1021/jacs.6b12443.s006
https://acs.figshare.com/articles/dataset/Enantioselective_Synthesis_of_6_Carbohelicenes/4579504
The
use of α-cationic phosphonites derived from TADDOL as
ancillary ligands has allowed a highly regio- and enantioselective
synthesis of substituted [6]carbohelicenes by sequential Au-catalyzed
intramolecular hydroarylation of diynes. Key for these results is
the modular structure of these new ligands, and the enhanced reactivity
that they impart to Au(I)-centers after coordination.
2017-01-23 19:23:12
coordination
ligand
Carbohelicene
reactivity
α- cationic phosphonites
enantioselective synthesis
TADDOL
diyne
carbohelicene
regio
sequential Au-catalyzed intramolecular hydroarylation
Enantioselective Synthesis