10.1021/jacs.6b12114.s001
Anton
A. Toutov
Anton
A.
Toutov
Kerry N. Betz
Kerry N.
Betz
David P. Schuman
David P.
Schuman
Wen-Bo Liu
Wen-Bo
Liu
Alexey Fedorov
Alexey
Fedorov
Brian M. Stoltz
Brian M.
Stoltz
Robert H. Grubbs
Robert H.
Grubbs
Alkali
Metal-Hydroxide-Catalyzed C(<i>sp</i>)–H Bond silylation
American Chemical Society
2016
KOH
Alkali Metal-Hydroxide-Catalyzed C
hydrosilane partners
Remarkably
strategy
silylation
functionalization
NaOH
scalable
Si
construction
catalyst
cross-dehydrogenative
scope
entry point
Bond
chemoselective
sp
alkyne
organosilane building blocks
bond
2016-12-27 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Alkali_Metal-Hydroxide-Catalyzed_C_i_sp_i_H_Bond_silylation/4572922
Disclosed
is a mild, scalable, and chemoselective catalytic cross-dehydrogenative
C–H bond functionalization protocol for the construction of
C(<i>sp</i>)–Si bonds in a single step. The scope
of the alkyne and hydrosilane partners is substantial, providing an
entry point into various organosilane building blocks and additionally
enabling the discovery of a number of novel synthetic strategies.
Remarkably, the optimal catalysts are NaOH and KOH.