%0 Journal Article
%A Weidner, Victoria
L.
%A Barger, Christopher J.
%A Delferro, Massimiliano
%A Lohr, Tracy L.
%A Marks, Tobin J.
%D 2017
%T Rapid, Mild, and Selective Ketone and Aldehyde Hydroboration/Reduction
Mediated by a Simple Lanthanide Catalyst
%U https://acs.figshare.com/articles/journal_contribution/Rapid_Mild_and_Selective_Ketone_and_Aldehyde_Hydroboration_Reduction_Mediated_by_a_Simple_Lanthanide_Catalyst/4547275
%R 10.1021/acscatal.6b03332.s001
%2 https://acs.figshare.com/ndownloader/files/7364845
%K 5 min
%K La NTMS
%K Selective Ketone
%K group compatibility
%K nitro groups
%K hydroboration
%K catalyst
%K Simple Lanthanide Catalyst Rapid
%X Rapid,
clean hydroboration of ketones and aldehydes with HBpin
is achieved using the homoleptic rare-earth catalyst La[N(SiMe3)2]3 (LaNTMS). The reaction
employs low catalyst loadings (0.01–1 mol % LaNTMS), proceeds rapidly (>99% in 5 min) at 25 °C, and is moderately
air-tolerant. Additionally, this hydroboration has good functional
group compatibility, including halides, nitro groups, and nitriles,
and is exclusively carbonyl-selective in the presence of alkenes and
alkynes.
%I ACS Publications