Microfluidic Pipette Tip for High-Purity and High-Throughput
Blood Plasma Separation from Whole Blood
Byeongyeon Kim
Sein Oh
Dongwon You
Sungyoung Choi
10.1021/acs.analchem.6b04587.s001
https://acs.figshare.com/articles/journal_contribution/Microfluidic_Pipette_Tip_for_High-Purity_and_High-Throughput_Blood_Plasma_Separation_from_Whole_Blood/4541335
Blood plasma separation from whole
blood is often limited by numerous
blood cells which can compromise separation processes and thus deteriorate
separation performance such as purity and throughput. To address this
challenge, we present a microfluidic pipet tip composed of slant array
ridges that enable autonomous blood cell focusing without significant
deviation as well as facilitating a high degree of parallelization
without compromising separation purity. With these advantages, we
achieved high-purity (99.88%) and high-throughput (904.3 μL
min<sup>–1</sup>) plasma separation from whole blood. In combination
with a smart pipet, we successfully demonstrated rapid, inexpensive,
and equipment-free blood plasma preparation for pretransfusion testing.
2017-01-11 18:53:26
pretransfusion testing
separation processes
separation purity
blood cells
separation performance
equipment-free blood plasma preparation
Whole Blood Blood plasma separation
High-Throughput Blood Plasma Separation
plasma separation
blood cell
Microfluidic Pipette Tip
microfluidic pipet tip
slant array ridges