Dimericbiscognienyne A: A Meroterpenoid Dimer from <i>Biscogniauxia</i> sp. with New Skeleton and Its Activity
Huan Zhao
Guo-Dong Chen
Jian Zou
Rong-Rong He
Sheng-Ying Qin
Dan Hu
Guo-Qiang Li
Liang-Dong Guo
Xin-Sheng Yao
Hao Gao
10.1021/acs.orglett.6b03264.s003
https://acs.figshare.com/articles/dataset/Dimericbiscognienyne_A_A_Meroterpenoid_Dimer_from_i_Biscogniauxia_i_sp_with_New_Skeleton_and_Its_Activity/4299779
Dimericbiscognienyne
A (<b>1</b>), an unusual diisoprenyl-cyclohexene-type
meroterpenoid dimer, was isolated from <i>Biscogniauxia</i> sp. together with three new monomeric diisoprenyl-cyclohexene-type
meroterpenoids (<b>2</b>–<b>4</b>) and one new
isoprenyl-benzoic acid-type meroterpenoid (<b>5</b>). All structures
were determined by extensive NMR spectroscopic methods, quantum chemical
calculations, chemical derivatization, and X-ray crystallography.
The formation of <b>1</b> is related to a unique intermolecular
redox coupling Diels–Alder adduct reaction. Their cytotoxicities
and short-term memory enhancement activities against Alzheimer’s
disease were assessed.
2016-12-09 12:20:57
quantum chemical calculations
Dimericbiscognienyne
monomeric diisoprenyl-cyclohexene-type meroterpenoids
NMR spectroscopic methods
Biscogniauxia sp
memory enhancement activities
diisoprenyl-cyclohexene-type meroterpenoid dimer
isoprenyl-benzoic acid-type meroterpenoid