10.1021/acs.analchem.6b04000.s001
James
N. Bull
James
N.
Bull
Michael S. Scholz
Michael S.
Scholz
Neville J. A. Coughlan
Neville J. A.
Coughlan
Akio Kawai
Akio
Kawai
Evan J. Bieske
Evan J.
Bieske
Monitoring Isomerization of Molecules in Solution Using Ion Mobility
Mass Spectrometry
American Chemical Society
2016
photochromic molecules
azoheteroarene compounds
Monitoring Isomerization
electrospray ion source
Ion Mobility Mass Spectrometry
absorption profiles
photostationary state
IMS technique
isomer populations
ion mobility spectrometer
LED array
photoactive molecules
sequential photoswitching events
UV
electrospray syringe
isomerization rates
silica capillary
2016-12-06 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Monitoring_Isomerization_of_Molecules_in_Solution_Using_Ion_Mobility_Mass_Spectrometry/4295474
An
ion mobility spectrometer (IMS) with an electrospray ion source
is used to investigate photo and thermal isomerization of photoactive
molecules in the electrospray syringe. A light emitting diode adjacent
to the syringe establishes a photostationary state that relaxes thermally
toward the more stable isomer once illumination ceases. The arrangement
is demonstrated by measuring <i>Z</i>–<i>E</i> thermal isomerization rates for several azoheteroarene compounds.
The IMS technique has a distinct advantage over UV–vis spectrophotometry
for measuring isomer populations in situations where there are multiple
isomers with overlapping absorption profiles. In another development,
an LED array adjacent to the silica capillary connecting the syringe
to the electrospray ion source, is used to activate photochromic molecules,
and investigate sequential photoswitching events.