Hyperpolarized Multi-Metal <sup>13</sup>C‑Sensors
for Magnetic Resonance Imaging
Anurag Mishra
Giorgio Pariani
Thomas Oerther
Markus Schwaiger
Gil G. Westmeyer
10.1021/acs.analchem.6b03546.s001
https://acs.figshare.com/articles/journal_contribution/Hyperpolarized_Multi-Metal_sup_13_sup_C_Sensors_for_Magnetic_Resonance_Imaging/4129134
We introduce hyperpolarizable <sup>13</sup>C-labeled probes that identify multiple biologically important
divalent metals via metal-specific chemical shifts. These features
enable NMR measurements of calcium concentrations in human serum in
the presence of magnesium. In addition, signal enhancement through
dynamic nuclear polarization (DNP) increases the sensitivity of metal
detection to afford measuring micromolar concentrations of calcium
as well as simultaneous multi-metal detection by chemical shift imaging.
The hyperpolarizable <sup>13</sup>C-MRI sensors presented here enable
sensitive NMR measurements and MR imaging of multiple divalent metals
in opaque biological samples.
2016-10-21 00:00:00
NMR measurements
metal-specific chemical shifts
hyperpolarizable 13 C-labeled probes
Magnetic Resonance Imaging
concentration
hyperpolarizable 13 C-MRI sensors
chemical shift imaging
divalent metals
DNP
detection
calcium