Hyperpolarized Multi-Metal <sup>13</sup>C‑Sensors for Magnetic Resonance Imaging Anurag Mishra Giorgio Pariani Thomas Oerther Markus Schwaiger Gil G. Westmeyer 10.1021/acs.analchem.6b03546.s001 https://acs.figshare.com/articles/journal_contribution/Hyperpolarized_Multi-Metal_sup_13_sup_C_Sensors_for_Magnetic_Resonance_Imaging/4129134 We introduce hyperpolarizable <sup>13</sup>C-labeled probes that identify multiple biologically important divalent metals via metal-specific chemical shifts. These features enable NMR measurements of calcium concentrations in human serum in the presence of magnesium. In addition, signal enhancement through dynamic nuclear polarization (DNP) increases the sensitivity of metal detection to afford measuring micromolar concentrations of calcium as well as simultaneous multi-metal detection by chemical shift imaging. The hyperpolarizable <sup>13</sup>C-MRI sensors presented here enable sensitive NMR measurements and MR imaging of multiple divalent metals in opaque biological samples. 2016-10-21 00:00:00 NMR measurements metal-specific chemical shifts hyperpolarizable 13 C-labeled probes Magnetic Resonance Imaging concentration hyperpolarizable 13 C-MRI sensors chemical shift imaging divalent metals DNP detection calcium