10.1021/acsomega.6b00163.s001 Chantelle J. Capicciotti Chantelle J. Capicciotti Ross S. Mancini Ross S. Mancini Tracey R. Turner Tracey R. Turner Toshie Koyama Toshie Koyama Matthew G. Alteen Matthew G. Alteen Malay Doshi Malay Doshi Takaaki Inada Takaaki Inada Jason P. Acker Jason P. Acker Robert N. Ben Robert N. Ben <i>O</i>‑Aryl-Glycoside Ice Recrystallization Inhibitors as Novel Cryoprotectants: A Structure–Function Study American Chemical Society 2016 cryoadditive cell damage ice nucleation blood cells ice recrystallization inhibition activity IRI RBC Novel Cryoprotectants ice recrystallization cryoprotectant cryopreservation ability 2016-10-24 17:36:26 Journal contribution https://acs.figshare.com/articles/journal_contribution/_i_O_i_Aryl-Glycoside_Ice_Recrystallization_Inhibitors_as_Novel_Cryoprotectants_A_Structure_Function_Study/4055802 Low-molecular-weight ice recrystallization inhibitors (IRIs) are ideal cryoprotectants that control the growth of ice and mitigate cell damage during freezing. Herein, we describe a detailed study correlating the ice recrystallization inhibition activity and the cryopreservation ability with the structure of <i>O</i>-aryl-glycosides. Many effective IRIs are efficient cryoadditives for the freezing of red blood cells (RBCs). One effective cryoadditive did not inhibit ice recrystallization but instead inhibited ice nucleation, demonstrating the significance of inhibiting both processes and illustrating the importance of this emerging class of cryoprotectants.