10.1021/acsomega.6b00163.s001
Chantelle
J. Capicciotti
Chantelle
J.
Capicciotti
Ross S. Mancini
Ross S.
Mancini
Tracey R. Turner
Tracey R.
Turner
Toshie Koyama
Toshie
Koyama
Matthew G. Alteen
Matthew G.
Alteen
Malay Doshi
Malay
Doshi
Takaaki Inada
Takaaki
Inada
Jason P. Acker
Jason P.
Acker
Robert N. Ben
Robert N.
Ben
<i>O</i>‑Aryl-Glycoside Ice Recrystallization
Inhibitors as Novel Cryoprotectants: A Structure–Function Study
American Chemical Society
2016
cryoadditive
cell damage
ice nucleation
blood cells
ice recrystallization inhibition activity
IRI
RBC
Novel Cryoprotectants
ice recrystallization
cryoprotectant
cryopreservation ability
2016-10-24 17:36:26
Journal contribution
https://acs.figshare.com/articles/journal_contribution/_i_O_i_Aryl-Glycoside_Ice_Recrystallization_Inhibitors_as_Novel_Cryoprotectants_A_Structure_Function_Study/4055802
Low-molecular-weight ice recrystallization
inhibitors (IRIs) are
ideal cryoprotectants that control the growth of ice and mitigate
cell damage during freezing. Herein, we describe a detailed study
correlating the ice recrystallization inhibition activity and the
cryopreservation ability with the structure of <i>O</i>-aryl-glycosides.
Many effective IRIs are efficient cryoadditives for the freezing of
red blood cells (RBCs). One effective cryoadditive did not inhibit
ice recrystallization but instead inhibited ice nucleation, demonstrating
the significance of inhibiting both processes and illustrating the
importance of this emerging class of cryoprotectants.