%0 Journal Article %A Han, Jing-Qiang %A Zhang, Huan-Huan %A Xu, Peng-Fei %A Luo, Yong-Chun %D 2016 %T Lewis Acid and (Hypo)iodite Relay Catalysis Allows a Strategy for the Synthesis of Polysubstituted Azetidines and Tetrahydroquinolines %U https://acs.figshare.com/articles/journal_contribution/Lewis_Acid_and_Hypo_iodite_Relay_Catalysis_Allows_a_Strategy_for_the_Synthesis_of_Polysubstituted_Azetidines_and_Tetrahydroquinolines/4003986 %R 10.1021/acs.orglett.6b02430.s003 %2 https://acs.figshare.com/ndownloader/files/6432279 %K amine %K Lewis acid-catalyzed nucleophilic ring opening %K Polysubstituted Azetidines %K diester %K cyclopropane %K catalysis strategy %X A catalytic [3 + 1]-annulation reaction between cyclopropane 1,1-diester and aromatic amine is developed based on the relay catalysis strategy. Lewis acid-catalyzed nucleophilic ring opening of cyclopropane 1,1-diester with aromatic amine and (hypo)­iodite-catalyzed C–N bond formation are combined successfully in one reaction. Using this reaction, biologically important azetidines and tetrahydroquinolines can be prepared directly. %I ACS Publications