%0 Journal Article
%A Kim, Inhye
%A Hee Han, Eun
%A Ryu, Jooyeon
%A Min, Jin-Young
%A Ahn, Hyungju
%A Chung, Young-Ho
%A Lee, Eunji
%D 2016
%T One-Dimensional Supramolecular Nanoplatforms for Theranostics
Based on Co-Assembly of Peptide Amphiphiles
%U https://acs.figshare.com/articles/journal_contribution/One-Dimensional_Supramolecular_Nanoplatforms_for_Theranostics_Based_on_Co-Assembly_of_Peptide_Amphiphiles/3830826
%R 10.1021/acs.biomac.6b00966.s001
%2 https://acs.figshare.com/ndownloader/files/5977170
%K chemical synthesis
%K water protons
%K intracellular delivery
%K One-Dimensional Supramolecular Nanoplatforms
%K MR imaging
%K T 1
%K metal ion
%K helical fibrils
%K PA coassembly
%K DOTA
%K supramolecular nanoplatform
%K DOX
%K β- sheet-forming peptide
%K target-specific cyclic octreotide
%K SSTR
%K multifunctional nanoparticles
%K PA function
%K contrast efficacy
%K block amphiphiles
%K Peptide Amphiphiles
%K MCF -7 cancer cells overexpressing SST receptor
%K drug loading
%K PA types
%K fibrillar nanotemplates
%K peptide amphiphiles
%K biocompatible nanomaterials
%X We
report a simple and facile strategy for the preparation of multifunctional
nanoparticles with programmable properties using self-assembly of
precisely designed block amphiphiles in an aqueous solution-state.
Versatile, supramolecular nanoplatform for personalized needs, particularly–theranostics,
was fabricated by coassembly of peptide amphiphiles (PAs) in aqueous
solution, replacing time-consuming and inaccessible chemical synthesis.
Fibrils, driven by the assembly of hydrophobic β-sheet–forming
peptide block, were utilized as a nanotemplate for drug loading within
their robust core. PAs were tagged with octreotide [somatostatin (SST)
analogue] for tumor-targeting or were conjugated with paramagnetic
metal ion (Gd3+)-chelating 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic
acid (DOTA) for magnetic resonance (MR) imaging. The two PA types
were coassembled to integrate each PA function into original fibrillar
nanotemplates. The adoption of a bulky target-specific cyclic octreotide
and β-sheet-forming peptide with enhanced hydrophobicity led
to a morphological transition from conventional fibrils to helical
fibrils. The resulting one-dimensional nanoaggregates allowed the
successful intracellular delivery of doxorubicin (DOX) to MCF-7 cancer
cells overexpressing SST receptor (SSTR) and MR imaging by enabling
high longitudinal (T1) relaxivity of water
protons. Correlation between the structural nature of fibrils formed
by PA coassembly and contrast efficacy was elucidated. The coassembly
of PAs with desirable functions may thus be a useful strategy for
the generation of tailor-made biocompatible nanomaterials.
%I ACS Publications