One-Dimensional Supramolecular Nanoplatforms for Theranostics
Based on Co-Assembly of Peptide Amphiphiles
Inhye Kim
Eun Hee Han
Jooyeon Ryu
Jin-Young Min
Hyungju Ahn
Young-Ho Chung
Eunji Lee
10.1021/acs.biomac.6b00966.s001
https://acs.figshare.com/articles/journal_contribution/One-Dimensional_Supramolecular_Nanoplatforms_for_Theranostics_Based_on_Co-Assembly_of_Peptide_Amphiphiles/3830826
We
report a simple and facile strategy for the preparation of multifunctional
nanoparticles with programmable properties using self-assembly of
precisely designed block amphiphiles in an aqueous solution-state.
Versatile, supramolecular nanoplatform for personalized needs, particularly–theranostics,
was fabricated by coassembly of peptide amphiphiles (PAs) in aqueous
solution, replacing time-consuming and inaccessible chemical synthesis.
Fibrils, driven by the assembly of hydrophobic β-sheet–forming
peptide block, were utilized as a nanotemplate for drug loading within
their robust core. PAs were tagged with octreotide [somatostatin (SST)
analogue] for tumor-targeting or were conjugated with paramagnetic
metal ion (Gd<sup>3+</sup>)-chelating 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic
acid (DOTA) for magnetic resonance (MR) imaging. The two PA types
were coassembled to integrate each PA function into original fibrillar
nanotemplates. The adoption of a bulky target-specific cyclic octreotide
and β-sheet-forming peptide with enhanced hydrophobicity led
to a morphological transition from conventional fibrils to helical
fibrils. The resulting one-dimensional nanoaggregates allowed the
successful intracellular delivery of doxorubicin (DOX) to MCF-7 cancer
cells overexpressing SST receptor (SSTR) and MR imaging by enabling
high longitudinal (<i>T</i><sub>1</sub>) relaxivity of water
protons. Correlation between the structural nature of fibrils formed
by PA coassembly and contrast efficacy was elucidated. The coassembly
of PAs with desirable functions may thus be a useful strategy for
the generation of tailor-made biocompatible nanomaterials.
2016-09-02 00:00:00
chemical synthesis
water protons
intracellular delivery
One-Dimensional Supramolecular Nanoplatforms
MR imaging
T 1
metal ion
helical fibrils
PA coassembly
DOTA
supramolecular nanoplatform
DOX
β- sheet-forming peptide
target-specific cyclic octreotide
SSTR
multifunctional nanoparticles
PA function
contrast efficacy
block amphiphiles
Peptide Amphiphiles
MCF -7 cancer cells overexpressing SST receptor
drug loading
PA types
fibrillar nanotemplates
peptide amphiphiles
biocompatible nanomaterials