%0 Journal Article %A Katritzky, Alan R. %A Pastor, Alfredo %A Voronkov, Michael %A Steel, Peter J. %D 2000 %T Novel One-Step Synthesis of Thiazolo[3,2-b]1,2,4-triazoles %U https://acs.figshare.com/articles/journal_contribution/Novel_One-Step_Synthesis_of_Thiazolo_3_2-_i_b_i_1_2_4-triazoles/3759969 %R 10.1021/ol990370w.s001 %2 https://acs.figshare.com/ndownloader/files/5867259 %K sulfoxide 4 %K COX %K thiazolo %K inhibitor %K chalcones 3 %K Synthesi %K triazole %K bi %K Thiazolo %K analysis %K triazolyl %X Reactions of chalcones 3af with bis(1H-1,2,4-triazolyl) sulfoxide 4 formed the thiazolo[3,2-b]1,2,4-triazoles 5af, which resemble closely some previously prepared COX-2 inhibitors. The structure of 5a was confirmed by X-ray analysis. %I ACS Publications