Enzymatic Selective Dehydration and
Skeleton Rearrangement of Paclitaxel
Precursors
Donghyun Lee
Mahn-Joo Kim
10.1021/ol990179m.s001
https://acs.figshare.com/articles/journal_contribution/Enzymatic_Selective_Dehydration_and_Skeleton_Rearrangement_of_Paclitaxel_Precursors/3759744
Enzymatic dehydration reactions to remove selectively the chemically least reactive 13-hydroxyl group of 10-deacetylbaccatin III and its derivatives
<b>2a</b><b>−</b><b>c</b> are described. The elimination of the 13-OH takes place with skeleton rearrangement, allowing us to synthesize some interesting diterpenoids
in good yields.
1999-08-12 00:00:00
elimination
Paclitaxel Precursors
Skeleton Rearrangement
derivatives 2
reactive
III
diterpenoid
Enzymatic
hydroxyl
deacetylbaccatin
OH
yield
dehydration reactions
Dehydration
skeleton rearrangement