Thia-Wittig-like Reactions as a New
Route for the Stereoselective Synthesis
of (<i>Z</i>)-Fluoroalkenoates
David Chevrie
Thierry Lequeux
Jean-Claude Pommelet
10.1021/ol990178u.s001
https://acs.figshare.com/articles/journal_contribution/Thia-Wittig-like_Reactions_as_a_New_Route_for_the_Stereoselective_Synthesis_of_i_Z_i_-Fluoroalkenoates/3759741
Stereoselective syntheses of (<i>Z</i>)-fluoroalkenoates <b>3a</b>−<b>g</b> have been developed in three steps from the readily available fluorosulfide <b>5</b> and
aldehydes. This preparation, involving a Durst reaction, was highly stereoselective and led to fluoroalkenes in 50−60% overall yields, without
purification of intermediates.
1999-10-17 00:00:00
stereoselective
Stereoselective Synthesis
preparation
intermediate
aldehyde
fluorosulfide 5
Fluoroalkenoate
fluoroalkene
synthese
fluoroalkenoate
yield
purification
New Route
Durst reaction