Integration of
Solution-Based Assays onto Lateral
Flow Device for One-Step Quantitative Point-of-Care Diagnostics Using
Personal Glucose Meter
JingJing Zhang
Zhe Shen
Yu Xiang
Yi Lu
10.1021/acssensors.6b00270.s001
https://acs.figshare.com/articles/journal_contribution/Integration_of_Solution-Based_Assays_onto_Lateral_Flow_Device_for_One-Step_Quantitative_Point-of-Care_Diagnostics_Using_Personal_Glucose_Meter/3749538
The
personal glucose meter (PGM) has been recently adapted as a
novel point-of-care (POC) device for the detection of various targets.
However, multistep target binding and enzymatic reactions in solution
make it difficult for end users to use this technology for POC detection.
To overcome this limitation, we report herein the integration of all
assay procedures in solution onto a lateral flow device (LFD) by demonstrating
competitive assays in a single step for quantitative detection of
both a small molecule (cocaine) and a large protein (streptavidin)
based on the glucose measured by PGMs. The LFD system demonstrated
here simplifies the POC operation significantly and thus allows an
even wider application of the PGM for POC diagnostics at home or in
low-resource settings.
2016-08-08 00:00:00
low-resource settings
Lateral Flow Device
end users
solution
LFD system
PGM
POC operation
glucose meter
Personal Glucose Meter
assay procedures
flow device
POC detection
multistep target binding
One-Step Quantitative Point-of-Care Diagnostics
novel point-of-care
POC diagnostics
Solution-Based Assays