Total Synthesis of (−)-Stemonine David R. Williams Khalida Shamim Jayachandra P. Reddy George S. Amato Stephen M. Shaw 10.1021/ol035368q.s001 https://acs.figshare.com/articles/journal_contribution/Total_Synthesis_of_-Stemonine/3748215 An enantioselective total synthesis of (−)-stemonine (<b>1</b>) is reported via a convergent assembly of the acyclic precursor <b>2</b>. Key transformations include a Staudinger−aza-Wittig reaction to form the central perhydroazepine ring system and an iodine-induced tandem cyclization to construct the pyrrolidino-butyrolactone framework. 2003-08-13 00:00:00 Key transformations cyclization convergent assembly enantioselective Staudinger stemonine synthesis framework tandem Stemonine Total Synthesis perhydroazepine ring system acyclic precursor 2