Total Synthesis of (−)-Stemonine
David R. Williams
Khalida Shamim
Jayachandra P. Reddy
George S. Amato
Stephen M. Shaw
10.1021/ol035368q.s001
https://acs.figshare.com/articles/journal_contribution/Total_Synthesis_of_-Stemonine/3748215
An enantioselective total synthesis of (−)-stemonine (<b>1</b>) is reported via a convergent assembly of the acyclic precursor <b>2</b>. Key transformations
include a Staudinger−aza-Wittig reaction to form the central perhydroazepine ring system and an iodine-induced tandem cyclization to construct
the pyrrolidino-butyrolactone framework.
2003-08-13 00:00:00
Key transformations
cyclization
convergent assembly
enantioselective
Staudinger
stemonine
synthesis
framework
tandem
Stemonine
Total Synthesis
perhydroazepine ring system
acyclic precursor 2