Rhodium(II,II) Dimer as an Efficient
Catalyst for Aziridination of
Sulfonamides and Amidation of Steroids
Jiang-Lin Liang
Shi-Xue Yuan
Philip Wai Hong Chan
Chi-Ming Che
10.1021/ol0270475.s001
https://acs.figshare.com/articles/journal_contribution/Rhodium_II_II_Dimer_as_an_Efficient_Catalyst_for_Aziridination_of_Sulfonamides_and_Amidation_of_Steroids/3744837
Unsaturated sulfonamides underwent direct intramolecular aziridination catalyzed by Rh<sub>2</sub>(OAc)<sub>4</sub> with PhI(OAc)<sub>2</sub> and Al<sub>2</sub>O<sub>3</sub> to give the corresponding
aziridine products in excellent yields (up to 98%) and with good to excellent conversions. High turnovers (up to 1375) were achieved. The
intermolecular rhodium-catalyzed amidation of cholesteryl acetate with PhINTs or PhI(OAc)<sub>2</sub>/NH<sub>2</sub>R as the nitrogen source exhibited both
excellent regio- and α-selectivity (α/β ratio up to 9:1).
2002-11-15 00:00:00
PhI
Efficient Catalyst
aziridine products
intramolecular aziridination
NH
High turnovers
Steroids Unsaturated sulfonamides
Al 2 O 3
nitrogen source
Rh 2
cholesteryl acetate