%0 Journal Article %A Harned, Andrew M. %A Mukherjee, Shubhasish %A Flynn, Daniel L. %A Hanson, Paul R. %D 2002 %T Ring-Opening Metathesis Phase-Trafficking (ROMpt) Synthesis:  Multistep Synthesis on Soluble ROM Supports %U https://acs.figshare.com/articles/journal_contribution/Ring-Opening_Metathesis_Phase-Trafficking_ROMpt_Synthesis_Multistep_Synthesis_on_Soluble_ROM_Supports/3744813 %R 10.1021/ol0270327.s001 %2 https://acs.figshare.com/ndownloader/files/5838177 %K ROM oligomers %K metathesi %K Synthesi %K multistep reaction sequence %X The use of ring-opening metathesis (ROM) oligomers as soluble supports for a multistep reaction sequence is described. A Mitsunobu reaction followed by an in situ ROMP-mediated phase-trafficking purification is utilized to generate soluble ROM oligomers that are isolated via precipitation with methanol. Once formed, the ROM oligomers serve as soluble supports for further solution-phase reactions, including a ring-closing metathesis. After each step, the support-bound products are isolated by precipitation with a suitable solvent. %I ACS Publications