10.1021/ol0267174.s001 Robert K. Boeckman, Robert K. Boeckman, Jing Zhang Jing Zhang Michael R. Reeder Michael R. Reeder Synthetic and Mechanistic Studies of the Retro-Claisen Rearrangement 4. An Application to the Total Synthesis of (+)-Laurenyne American Chemical Society 2002 Synthetic Application ether cyclization strategy 4. sequential synthesis construction Mechanistic Studies Rearrangement marine Laurenyne Total Synthesis functionalized chiral vinyl cyclobutane rearrangement 2002-09-27 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Synthetic_and_Mechanistic_Studies_of_the_Retro-Claisen_Rearrangement_4_An_Application_to_the_Total_Synthesis_of_-Laurenyne/3744213 A novel asymmetric total synthesis of marine natural product (+)-Laurenyne has been achieved. The key elements of the strategy are the sequential metal ion-templated S<sub>N</sub>2‘ cyclization affording a highly functionalized chiral vinyl cyclobutane and a retro-Claisen rearrangement for the construction of an eight-membered ring ether.