Celestini, Paolo Danieli, Bruno Lesma, Giordano Sacchetti, Alessandro Silvani, Alessandra Passarella, Daniele Virdis, Andrea <i>trans</i>-6-Aminocyclohept-3-enols, a New Designed Polyfunctionalized Chiral Building Block for the Asymmetric Synthesis of 2-Substituted-4-hydroxypiperidines <i>trans</i>-6-Aminocyclohept-3-enols <b>18</b> and <i>ent</i>-<b>18</b> are new designed polyfunctionalized chiral building blocks for piperidine alkaloids synthesis and are prepared in high yields from the enzymatically derived cyclohept-3-ene-1,6-diol monoacetate (−)-<b>8</b>. Efficient highly enantioselective syntheses of <i>cis</i>-4-hydroxypipecolic acid (<b>1</b>) and piperidines <b>3</b> and <b>4</b>, in both enantiomeric forms, are described. ci;Aminocyclohept;Efficient;enantiomeric forms;cyclohept;New;enzymatically;polyfunctionalized chiral building blocks;enantioselective syntheses;Substituted;ent;hydroxypipecolic;Asymmetric Synthesis;Polyfunctionalized Chiral Building Block;piperidine alkaloids synthesis;piperidines 3;monoacetate;tran;yield;acid 2002-03-23
    https://acs.figshare.com/articles/journal_contribution/_i_trans_i_-6-Aminocyclohept-3-enols_a_New_Designed_Polyfunctionalized_Chiral_Building_Block_for_the_Asymmetric_Synthesis_of_2-Substituted-4-hydroxypiperidines/3742368
10.1021/ol025683x.s001