%0 Journal Article %A Celestini, Paolo %A Danieli, Bruno %A Lesma, Giordano %A Sacchetti, Alessandro %A Silvani, Alessandra %A Passarella, Daniele %A Virdis, Andrea %D 2002 %T trans-6-Aminocyclohept-3-enols, a New Designed Polyfunctionalized Chiral Building Block for the Asymmetric Synthesis of 2-Substituted-4-hydroxypiperidines %U https://acs.figshare.com/articles/journal_contribution/_i_trans_i_-6-Aminocyclohept-3-enols_a_New_Designed_Polyfunctionalized_Chiral_Building_Block_for_the_Asymmetric_Synthesis_of_2-Substituted-4-hydroxypiperidines/3742368 %R 10.1021/ol025683x.s001 %2 https://acs.figshare.com/ndownloader/files/5834196 %K ci %K Aminocyclohept %K Efficient %K enantiomeric forms %K cyclohept %K New %K enzymatically %K polyfunctionalized chiral building blocks %K enantioselective syntheses %K Substituted %K ent %K hydroxypipecolic %K Asymmetric Synthesis %K Polyfunctionalized Chiral Building Block %K piperidine alkaloids synthesis %K piperidines 3 %K monoacetate %K tran %K yield %K acid %X trans-6-Aminocyclohept-3-enols 18 and ent-18 are new designed polyfunctionalized chiral building blocks for piperidine alkaloids synthesis and are prepared in high yields from the enzymatically derived cyclohept-3-ene-1,6-diol monoacetate (−)-8. Efficient highly enantioselective syntheses of cis-4-hydroxypipecolic acid (1) and piperidines 3 and 4, in both enantiomeric forms, are described. %I ACS Publications