%0 Journal Article
%A Celestini, Paolo
%A Danieli, Bruno
%A Lesma, Giordano
%A Sacchetti, Alessandro
%A Silvani, Alessandra
%A Passarella, Daniele
%A Virdis, Andrea
%D 2002
%T trans-6-Aminocyclohept-3-enols, a New
Designed Polyfunctionalized Chiral
Building Block for the Asymmetric
Synthesis of
2-Substituted-4-hydroxypiperidines
%U https://acs.figshare.com/articles/journal_contribution/_i_trans_i_-6-Aminocyclohept-3-enols_a_New_Designed_Polyfunctionalized_Chiral_Building_Block_for_the_Asymmetric_Synthesis_of_2-Substituted-4-hydroxypiperidines/3742368
%R 10.1021/ol025683x.s001
%2 https://acs.figshare.com/ndownloader/files/5834196
%K ci
%K Aminocyclohept
%K Efficient
%K enantiomeric forms
%K cyclohept
%K New
%K enzymatically
%K polyfunctionalized chiral building blocks
%K enantioselective syntheses
%K Substituted
%K ent
%K hydroxypipecolic
%K Asymmetric Synthesis
%K Polyfunctionalized Chiral Building Block
%K piperidine alkaloids synthesis
%K piperidines 3
%K monoacetate
%K tran
%K yield
%K acid
%X trans-6-Aminocyclohept-3-enols 18 and ent-18 are new designed polyfunctionalized chiral building blocks for piperidine alkaloids synthesis
and are prepared in high yields from the enzymatically derived cyclohept-3-ene-1,6-diol monoacetate (−)-8. Efficient highly enantioselective
syntheses of cis-4-hydroxypipecolic acid (1) and piperidines 3 and 4, in both enantiomeric forms, are described.
%I ACS Publications