10.1021/ol025683x.s001
Paolo Celestini
Paolo
Celestini
Bruno Danieli
Bruno
Danieli
Giordano Lesma
Giordano
Lesma
Alessandro Sacchetti
Alessandro
Sacchetti
Alessandra Silvani
Alessandra
Silvani
Daniele Passarella
Daniele
Passarella
Andrea Virdis
Andrea
Virdis
<i>trans</i>-6-Aminocyclohept-3-enols, a New
Designed Polyfunctionalized Chiral
Building Block for the Asymmetric
Synthesis of
2-Substituted-4-hydroxypiperidines
American Chemical Society
2002
ci
Aminocyclohept
Efficient
enantiomeric forms
cyclohept
New
enzymatically
polyfunctionalized chiral building blocks
enantioselective syntheses
Substituted
ent
hydroxypipecolic
Asymmetric Synthesis
Polyfunctionalized Chiral Building Block
piperidine alkaloids synthesis
piperidines 3
monoacetate
tran
yield
acid
2002-03-23 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/_i_trans_i_-6-Aminocyclohept-3-enols_a_New_Designed_Polyfunctionalized_Chiral_Building_Block_for_the_Asymmetric_Synthesis_of_2-Substituted-4-hydroxypiperidines/3742368
<i>trans</i>-6-Aminocyclohept-3-enols <b>18</b> and <i>ent</i>-<b>18</b> are new designed polyfunctionalized chiral building blocks for piperidine alkaloids synthesis
and are prepared in high yields from the enzymatically derived cyclohept-3-ene-1,6-diol monoacetate (−)-<b>8</b>. Efficient highly enantioselective
syntheses of <i>cis</i>-4-hydroxypipecolic acid (<b>1</b>) and piperidines <b>3</b> and <b>4</b>, in both enantiomeric forms, are described.