Stereoselective Bromination−Suzuki Cross-Coupling of Dehydroamino Acids To Form Novel Reverse-Turn Peptidomimetics:  Substituted Unsaturated and Saturated Indolizidinone Amino Acids ZhangJunyi XiongChiyi WangWei YingJinfa HrubyVictor J. 2002 A general and efficient methodology has been developed to prepare the C4-substituted dipeptide reverse-turn mimetics unsaturated (<b>9a</b>, <b>10a</b>) and saturated (<b>11a</b>) azabicyclo[4.3.0] alkane amino acid derivatives. The side chain was introduced by bromination of dehydroamino acid intermediates followed by Suzuki coupling. Hydrogenation of the bicyclic dehydroamino acid <b>9a</b> afforded saturated bicyclic lactam <b>11a</b>. This approach can be further explored for the synthesis of a variety of such β-turn mimetics with aryl and alkyl side chain functionalities.