One-Pot Synthesis of Glucosamine
Oligosaccharides
Micha Fridman
Dmitry Solomon
Shay Yogev
Timor Baasov
10.1021/ol017054d.s002
https://acs.figshare.com/articles/journal_contribution/One-Pot_Synthesis_of_Glucosamine_Oligosaccharides/3741252
Tuning the reactivity of glycosyl donors derived from 2-amino-2-deoxy glucose by selective introduction of different N-protecting (NPhth and
NHTroc) and anomeric leaving groups (ethylthio and phenylthio) enabled highly efficient oligosaccharide synthesis in a one-pot manner.
One-pot sequential glycosylation of three and four units of 2-amino-2-deoxy glucose gave trisaccharides and tetrasaccharide in 50−81%
yields.
2001-12-29 00:00:00
glycosyl donors
manner
ethylthio
anomeric
NPhth
glycosylation
introduction
reactivity
sequential
tetrasaccharide
glucose
yield
phenylthio
trisaccharide
NHTroc
oligosaccharide synthesis
Glucosamine Oligosaccharides Tuning
Synthesi