%0 Journal Article %A Marshall, James A. %A Chobanian, Harry R. %A Yanik, Mathew M. %D 2001 %T Lipase-Mediated Resolution of 4-TMS-3-butyn-2-ol and Use of the Mesylate Derivatives as a Precursor to a Highly Stereoselective Chiral Allenylindium Reagent %U https://acs.figshare.com/articles/journal_contribution/Lipase-Mediated_Resolution_of_4-TMS-3-butyn-2-ol_and_Use_of_the_Mesylate_Derivatives_as_a_Precursor_to_a_Highly_Stereoselective_Chiral_Allenylindium_Reagent/3740313 %R 10.1021/ol016605x.s001 %2 https://acs.figshare.com/ndownloader/files/5832081 %K TMS %K mesylate derivatives %K enantio %K aldehyde %K diastereoselective additions %K Precursor %K regio %K trimethylsilyl %K Mesylate Derivatives %K Stereoselective Chiral Allenylindium Reagent %K homopropargylic alcohol adducts %K procedure %X An improved procedure for the resolution of 4-trimethylsilyl-3-butyn-2-ol has been developed. The mesylate derivatives of the resolved alcohols have been found to undergo highly enantio-, regio-, and diastereoselective additions to aldehydes, leading to homopropargylic alcohol adducts. %I ACS Publications