Progress toward the Total Synthesis of Callipeltin A (I):  Asymmetric Synthesis of (3<i>S</i>,4<i>R</i>)-3,4-Dimethylglutamine Bo Liang Patrick J. Carroll Madeleine M. Joullié 10.1021/ol006679t.s005 https://acs.figshare.com/articles/journal_contribution/Progress_toward_the_Total_Synthesis_of_Callipeltin_A_I_Asymmetric_Synthesis_of_3_i_S_i_4_i_R_i_-3_4-Dimethylglutamine/3737517 During the total synthesis of the novel cyclic depsipeptide callipeltin A (<b>1</b>), the unit (3<i>S</i>,4<i>R</i>)-3,4-dimethylglutamine, was successfully synthesized by asymmetric Michael addition and subsequent electrophilic azidation. The key feature of this approach is the generation of three adjacent stereogenic centers using the same camphorsultam chiral auxiliary. 2000-12-02 00:00:00 generation Callipeltin Dimethylglutamine electrophilic azidation Progress Michael addition Asymmetric dimethylglutamine novel cyclic depsipeptide callipeltin approach synthesis stereogenic centers Total Synthesis camphorsultam chiral