Progress toward the Total Synthesis of
Callipeltin A (I): Asymmetric Synthesis
of (3<i>S</i>,4<i>R</i>)-3,4-Dimethylglutamine
Bo Liang
Patrick J. Carroll
Madeleine M. Joullié
10.1021/ol006679t.s002
https://acs.figshare.com/articles/journal_contribution/Progress_toward_the_Total_Synthesis_of_Callipeltin_A_I_Asymmetric_Synthesis_of_3_i_S_i_4_i_R_i_-3_4-Dimethylglutamine/3737514
During the total synthesis of the novel cyclic depsipeptide callipeltin A (<b>1</b>), the unit (3<i>S</i>,4<i>R</i>)-3,4-dimethylglutamine, was successfully synthesized
by asymmetric Michael addition and subsequent electrophilic azidation. The key feature of this approach is the generation of three adjacent
stereogenic centers using the same camphorsultam chiral auxiliary.
2000-12-02 00:00:00
generation
Callipeltin
Dimethylglutamine
electrophilic azidation
Progress
Michael addition
Asymmetric
dimethylglutamine
novel cyclic depsipeptide callipeltin
approach
synthesis
stereogenic centers
Total Synthesis
camphorsultam chiral